Genomics

Advances in the technology to read people’s DNA have made it so much faster and cheaper that we can now read the genetic code of many different genes at once, increasingly by sequencing the entire genome of a patient or their cancer.

Comparing a genome sequence from a tumour cell with one from a healthy cell allows our researchers to pinpoint the genetic changes that are involved in causing cancer, helping us to create new and improved treatments. We can also learn about genetic changes people inherit which may increase their risk of cancer, and this can lead to new ways of preventing the disease.

This page highlights recent news stories, blog posts and videos that concern the use of genomics technologies in cancer research.

Recent stories on genomics technologies in cancer research

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Algorithm offers new way to spot patients likely to respond to immunotherapy

09/03/23

Scientists have developed a new way of using cancers’ DNA to spot cancer patients who may benefit from immunotherapy.
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Landmark Nature papers unveil ‘dark matter’ shaping cancer behaviour

26/10/22

Cancers can evolve to become more aggressive without relying only on DNA mutations, two major studies published simultaneously in Nature reveal.
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Deliberately damaging DNA could boost the effectiveness of immunotherapy in kidney cancer

20/09/22

DNA damage is one of the foundational causes of cancer. But researchers have now found that deliberately causing DNA damage – by delivering additional treatments like radiotherapy – could improve the effectiveness of immunotherapy for some people with kidney cancer.
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Artificial intelligence unlocks ‘treasure trove’ of billions of cancer samples

07/09/22

Scientists have developed an artificial intelligence (AI) method that could unlock a research ‘treasure trove’ of cancer genomes from billions of preserved tissue samples stored routinely at hospitals over decades.
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‘Junk’ DNA could lead to cancer by stopping copying of DNA

19/07/22

Scientists have found that non-coding ‘junk’ DNA, far from being harmless and inert, could potentially contribute to the development of cancer.
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Professors Kristian Helin and Trevor Graham elected as Fellows of the Academy of Medical Sciences

11/05/22

Professor Kristian Helin, Chief Executive and President at The Institute of Cancer Research, London, and Professor Trevor Graham, Director of the ICR’s Centre for Evolution and Cancer, have been awarded prestigious Fellowships for the Academy of Medical Sciences (AMS).
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Common genetic mutation allows cancer cells to gain extra chromosomes which help them survive

09/05/22

Scientists have found a genetic mutation that results in cancer cells being able to tolerate having an abnormal number of chromosomes – a condition which normally kills cells – allowing them to adapt to their environment and continue to grow.
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Damaged DNA – wielding a double-edged sword against cancer

25/04/22

This DNA Day, we look at how our scientists are seeking to understand how cells respond to damage to DNA – and the tricks cancer uses to stay alive despite suffering genetic damage.