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Group leaders
We're recruiting the top figures in cancer research to work in a vibrant and confident culture that consistently produces world-changing research.
Beginning your career
Joining as a group leader, you will be given outstanding support to help you to continue to develop in your career. You’ll receive a competitive start-up package of funding, as well as the guidance you need to start up your first lab – from lab space and equipment, to help recruiting postdoctoral students, technicians and PhD students.
You will be enrolled in a development programme aimed at early career researchers, providing you with the skills and techniques required to make you a confident and effective group leader. We also have a wealth of training programmes run by out Learning and Development department that allow you to develop as a manager.
You’ll have the space to grow, excel and make your mark while gaining dedicated support with grant applications, leadership training.
We support our scientists with state-of-the-art platform technologies and expert facilities staff, providing cutting-edge facilities for microscopy, imaging, sequencing, proteomics, X-ray crystallography and much more.
Senior positions
To become part of our career faculty, you will be an established senior researcher and have the proven leadership skills and international research credibility to direct major scientific programmes, and build and manage a motivated and high-performing scientific team.
Our culture emphasises the importance of collaborative working to address the big challenges in cancer research, and you will be expected to form part of the wider ICR team. You will also recruit and develop the research leaders of the future.
What we offer
We are the top-ranked higher education institution in the UK for research quality and impact, we are also rated among the world’s best universities in measures of innovation and collaboration with industry.
We offer support throughout the process of relocating and embedding your team at the ICR, and as you continue to build on your achievements.
We understand that access to world-class facilities and technology platforms is essential to maximise the progress you are able to make with your research and will work with you to shape access to facilities to meet your needs.
As an intellectual leader in your field, you will have the chance to use your platform at the ICR to influence and contribute to wider public discussions to ensure your research has the maximum benefit for people with cancer.
And with access to expertise across the spectrum of cancer research disciplines, you will build on our success – leading innovation through new collaborations across the ICR, and with external collaborators in academia, healthcare and industry.
Scientific vacancies at the ICR
Postdoctoral Training Fellow
Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]
Higher Scientific Officer - Drug Discovery Biology, Centre for Protein Degradation
We are seeking to recruit a Higher Scientific Officer within the Induced Proximity Therapeutics (IPT) Team in the ICR Centre for Protein Degradation to support our molecular glue and PROTAC drug discovery projects and expand induced proximity technology. The IPT team focuses on three main areas of research: Cancer target validation Screening, profiling and molecular mechanism of action of molecular glue and PROTAC degraders Novel E3 ligase biology and ligand discovery The successful candidate will work in a multidisciplinary team and play a key role in target validation, developing in vitro and cell-based assays, and pharmacological characterisation of novel molecular glue degraders and PROTACs, but may also contribute to other activities. About you The successful candidate: Will be a strong team player who is technically minded and passionate about science and cancer drug discovery Will hold a first degree, and preferably a PhD, in biological science or biochemistry Will have experience in cancer biology/target validation, genetic manipulation techniques, in vitro and cell-based assay development and pharmacological compound profiling Experience in targeted protein degradation will be a significant advantage. Department/Directorate Information This position will be based in the ICR's Centre for Protein Degradation, a part of the Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signalling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists, oncology specialists and physicians on discovering new medicines - molecular glue degraders and PROTACs - using innovative screening platforms and characterising their mechanisms of action, as well as expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation). Our research provides a nucleus for the academics and pharmaceutical industry to explore therapeutic potential of targeted protein degradation from laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients. What we offer A dynamic and supportive research environment in one of the successful academic cancer drug discovery centres in the UK Access to state-of-the-art facilities and professional development Collaboration with leading drug discovery and oncology scientist Competitive salary and pension To learn more about this role, please download the attached job pack. For informal inquiries, please contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation via email: [email protected].
Data Scientist
Under the guidance of Professor Trevor Graham, we are seeking to recruit a Data Scientist to support Data Science research across the ICR. The successful candidate will work broadly across three research areas: integrative analysis of large datasets, analysis of single cell data and analysis of spatial data as outlined below. There is a particular emphasis for end-stage analysis of single cell and spatial data. About you The successful candidate must have: A PhD in quantitative subject, or likely to be awarded PhD in the near future. Undergraduate degree, or Masters or equivalent in a quantitative subject. Skills in bioinformatics computing coding, in languages including R, Python and other scripting languages as is appropriate. Experience of using high performance computing (HPC) systems for scientific computing. Experience of computational biology research methodologies pertinent to the role. Department/Directorate Information The Data Science Committee is chaired by Professor Trevor Graham, providing academic leadership of data science at the ICR to maximise the impact of our cancer research, by applying innovative data science and computation tools (in addition to our traditional areas of strength) to tackle the important cancer questions and ensuring infrastructure is considered to enable this. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Prof Trevor Graham [email protected].
Senior Laboratory Manager
Under the guidance of Dr Abby Cook, we are seeking to recruit a Senior Laboratory Manager to contribute to the safe and efficient operation of the laboratories in the Centre for Cancer Drug Discovery and Division of Cancer Therapeutics. The successful candidate will play a key role in maintaining the safe and efficient operations of laboratories, liaising with Division teams and professional services across ICR, managing space and equipment in the laboratories, compliance with key regulatory requirements, sustainable practices, and dealing with day-to-day laboratory issues. About you The successful candidate must have: Undergraduate degree in a scientific discipline Excellent communication skills, verbal and written, with the ability to give clear instructions – essential for training purposes and dissemination of safety critical and organisational information to mixed discipline teams Excellent record keeping to an auditable standard Knowledge of good lab practices and associated legislative compliance. In particular of Health & Safety, GCP and HTA regulations. Good organisational skills with ability to be flexible in order to react to issues and to prioritise so that delays to research are kept to a minimum while working to meet objectives and deadlines Problem solving skills and flexible proactive approach to dealing with problems, and preventing them before they arise Previous working experience of a research lab Department/Directorate Information The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutions, with an outstanding track record of achievement dating back more than 100 years. Our mission is to make the discoveries that defeat cancer. As well as being one of the UK’s leading higher education institutions in research quality and impact, the ICR is consistently ranked as one of the world’s most successful for industry collaboration. As a member institution of the University of London, we also provide postgraduate higher education of international distinction. We are also a charity and rely on the support of partner organisations, funders, donors and the general public. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Abby Cook via email at: [email protected]