FAST
Prospective randomised clinical trial testing 5.7 Gy and 6.0 Gy fractions of whole breast radiotherapy in terms of late normal tissue responses and tumour control.
Disease site: Breast cancer
Treatment Modality: Radiotherapy
Status: In follow-up
Further information for potential participants
Patient Information Sheet (Version 4a)
Patient Information Sheet (Version 4b)
Further information for healthcare professionals
Chief Investigator: Professor John Yarnold, The Institute of Cancer Research & Royal Marsden NHS Foundation Trust
ICR-CTSU Scientific Lead: Professor Judith Bliss
ISRCTN: 62488883
Sponsor: The Institute of Cancer Research
Funding: Cancer Research UK programme grant funding
A lay summary in plain English is available from Cancer Research UK
Publications and presentations
Ten-Year Results of FAST: A Randomized Controlled Trial of 5-Fraction Whole-Breast Radiotherapy for Early Breast Cancer - Adrian Murray Brunt, Joanne S Haviland, Mark Sydenham, Rajiv K Agrawal, Hafiz Algurafi, Abdulla Alhasso, Peter Barrett-Lee, Peter Bliss, David Bloomfield, Joanna Bowen, Ellen Donovan, Andy Goodman, Adrian Harnett, Martin Hogg, Sri Kumar, Helen Passant, Mary Quigley, Liz Sherwin, Alan Stewart, Isabel Syndikus, Jean Tremlett, Yat Tsang, Karen Venables, Duncan Wheatley, Judith M Bliss, John R Yarnold - J Clin Oncol. 2020 Oct 1;38(28):3261-3272. doi:10.1200/JCO.19.02750. Epub 2020 Jul 14.
The FAST Trialists Group. First results of the randomised UK FAST Trial of radiotherapy hypofractionation for treatment of early breast cancer (CRUKE/04/015). Radiother. Oncol. 2011;100(1):93-100
Brunt AM, Sydenham M, Bliss J, et al. A 5-fraction regimen of adjuvant radiotherapy for women with early breast cancer: first analysis of the randomised UK FAST Trial (ISRCTN62488883, CRUKE/04/015). European Journal of Cancer Supplements 2009;7(3):2
Tsang YM, Venables K, Sydenham M, on behalf of the FAST Working Party. Interim quality assurance (QA) analysis of treatment plans in the 'Faster Radiotherpay for Breast Cancer patients' (FAST) Trial. NCRI Cancer Conference; 2006.
Sydenham M, Haviland J, Donovan E, Venables K, Bliss JM, Yarnold J, on behalf of the FAST Trial Management Group. Further testing of radiotherapy hypofractionation (fewer, larger fractions) in early breast cancer - The FAST Trial. NCRI Cancer Conference; 2006.
Yarnold J, Bloomfield D, LeVay J, et al. Prospective randomised trial testing 5.7 Gy and 6.0 Gy fractions of whole-breast radiotherapy in women with early breast cancer (FAST Trial). Clin. Oncol. (R. Coll. Radiol). 2004;16(6):S30 #P3.02
Major trial shows prolonged benefit of olaparib in early-stage inherited breast cancer
