Mr Myles Smith

Biography

Myles Smith is a Consultant General Surgeon and Surgical Oncologist. After completing his surgical training through the Royal College of Surgeons in Ireland's Higher Surgical Training scheme, he pursued a General Surgical Oncology Fellowship at the University of Toronto. He joined The Royal Marsden NHS Foundation Trust in 2015, where he focuses on sarcoma and melanoma treatment.

His postgraduate research at University College Cork, under the mentorship of Professors TG Cotter and HP Redmond, explored tumour heterogeneity and local recurrence mechanisms after cancer surgery. Since joining The Institute of Cancer Research and RMH, he has combined clinical practice with research in biomarkers, advanced imaging, and minimally invasive techniques, aiming to improve outcomes for cancer patients through collaboration and innovation.

Research Themes and Focus Since Joining ICR and RMH

Since joining The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, my research has centered on integrating cutting-edge technologies and methodologies to improve outcomes in cancer treatment. My work spans molecular biomarker discovery, advanced imaging techniques, and innovative surgical approaches tailored to sarcoma and melanoma patients. Collaborative efforts have been a cornerstone of this journey, enabling the translation of scientific discoveries into clinical applications that advance patient care. Mr. Smith's research subsequently has focused on molecular biomarkers in solid tumours, including incorporating new imaging techniques into the surgical cancer pathway.

In collaboration with Imperial College and the Convergence Science Centre, we have worked on developing 3D holograms from imaging, co-registration, augmented reality (AR), and computer vision to plan and guide surgery. Additionally, partnerships with market-leading industry players, such as Holocare, have supported these advancements.

Research Interests

• Clinical Outcomes
  • Focused on improving perioperative care and long-term survival rates for sarcoma and melanoma patients. Key areas include optimizing treatment protocols and identifying predictive biomarkers.
• Clinical Guidelines
  • NICE Melanoma Guideline Update 2024
  • NICE Melanoma QSAC 2024
  • UK AUG Melanoma Guidelines Chair
  • British Sarcoma Group GIST Guidelines 2025
• Convergence Science
  • Mixed and augmented reality
  • Computer vision and AI
  • Precision Surgery
  • Member of BRC Precision Surgery O-TRC
  • Fluorescence guided surgery
• Clinical Trials
  • Member of the RMH Perioperative Clinical Trials Unit
  • PI for:
    • PPPIMS
  • Local PI for:
    • COLA
    • MELMART-II

Research Team and Collaborators

My research is supported by a dedicated team and collaborative efforts with multidisciplinary partners. Key contributors include:

• Imperial College and the Convergence Science Centre, particularly Dr. Stamatia Giannarou, for integrating augmented reality, computer vision, and AI into surgical practices.
• Industry partners such as Holocare for advancing 3D holographic imaging in surgical applications.
• Clinical and academic colleagues at The Institute of Cancer Research and The Royal Marsden, focusing on biomarker discovery and clinical trials.
• PhD and clinical fellows who contribute through research projects and electives, enhancing our innovative approaches in cancer treatment.
• Active collaborations with the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPWG) and other international research partners.

Publications

• PubMed Bibliography
• Google Scholar

Join Our Team as a Research Fellow

We are always interested in hearing from talented individuals who are keen to join our research team. Opportunities to become a Research Fellow are announced and updated regularly via NHS TRAC Jobs, The Royal Marsden NHS Foundation Trust (RMH) website , and our social media channels. For initial inquiries, please contact our PA at [email protected].

For clinicians interested in pursuing an MD(Res) or PhD, detailed information is available through The Institute of Cancer Research (ICR) at MD(Res) and PhD Opportunities for Clinicians.