Translational Sarcoma, Melanoma and Rare Tumour Surgery Group

Mr Myles Smith's group aims to translate basic science innovations generated at the ICR to advance the surgical treatment of cancer – for example, evaluating molecular markers to aid the definition of cancer at the time of surgery.


Our group aims to help the translation of imaging technologies developed at The Institute of Cancer Research to the clinic and bedside.

Tumour-specific preoperative and intraoperative imaging with targeted molecular probes holds great promise in cancer surgery. Improved ability to define the distribution of cancer at the time of surgery would better help define the extent and adequacy of resection, while minimising excision of healthy tissue.

Other benefits include intraoperative staging and the guidance of adjuvant treatments. Successful application of intraoperative targeted molecular imaging to cancer surgery has the potential to translate into improved local control and survival, while reducing the impact of curative interventions. We aim to help the translation of imaging technologies developed at The Institute of Cancer Research to the clinic and bedside.

Myles Smith

Honorary Faculty:

Translational Sarcoma, Melanoma and Rare Tumour Surgery Mr Myles Smith

Myles Smith is a Consultant General Surgeon and Surgical Oncologist. After completing his surgical training through the Royal College of Surgeons in Ireland's Higher Surgical Training scheme, he pursued a General Surgical Oncology Fellowship at the University of Toronto. He joined The Royal Marsden NHS Foundation Trust in 2015, where he focuses on sarcoma and melanoma treatment.

Recent discoveries from this group

AI-style image illustrating virus particles surrounded by different types of white blood cells

07/11/25

A pioneering clinical trial has demonstrated for the first time that two existing treatments can be combined to potentially improve outcomes for sarcoma and melanoma patients with advanced tumours in their limbs.
Image of hand holding syringe

19/10/25

A new type of cancer treatment which is given via an injection under the skin has shown early signs of success in patients with advanced head and neck cancer.
Two hands, each holding a jigsaw piece and bringing the two together

08/10/25

A new study has revealed a promising therapeutic strategy for pancreatic cancer, offering new hope for people living with this disease.

20/08/25

Two studies have uncovered how combining a cancer-killing reovirus with targeted cancer drugs can dramatically boost immune responses and tumour destruction – offering a promising route to more effective, personalised cancer therapies.