Scientist mixing solutions in lab

Study and Careers

As the UK’s leading academic research centre, The Institute of Cancer Research offers a fantastic work and study environment, great opportunities for development and the chance to make a real difference for cancer patients. We aim to train, recruit and develop the best – with positions for outstanding scientists and clinicians, and the most talented professional or administrative staff.

Studying at the ICR

Our competitive programmes and specialised courses are designed for the next generation of cancer researchers and clinicians.

Scientists in lab - Four scientists working in a lab

PhD projects and opportunities

We offer 20 fully funded PhD studentships each year. Our main round opens in October, but we also advertise projects throughout the year. 

 

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Opportunities for clinicians

At The Institute of Cancer Research, London, we offer clinicians a variety of opportunities – from a taught master's course in Oncology, to fellowships providing protected time for research, and higher research degrees.

MSc in Oncology

The Taught Course in Oncology is a day-release modular programme designed for medically qualified candidates who intend to pursue a professional career in some aspect of clinical or medical oncology, either as a clinical academic or a clinician.

Why study with us?

By providing world-class expertise and support to students at The Institute of Cancer Research, we hope to advance cancer research and clinical practice not only within our organisation, but throughout the field.

Varun Ramaswamy is a third-year PhD student at the ICR. He is working on a collaborative project between the Division of Cancer Therapeutics and the Division of Structural Biology that aims to solve the 3D structure of a protein called HSET using cryo-electron microscopy and complementary biophysical techniques.

What is your educational/work background?

I did my undergraduate degree in Genetic Engineering at SRM University, India. In 2016, I moved to London to do an MRes in Molecular Biophysics at King’s College London.

Why did you want to study at the ICR?

During my master’s degree, I had the opportunity to work with researchers at the ICR and collect some electron microscopy data. I was really fascinated by the technique and the facility at the ICR and kept in touch with the team about any future research opportunities.

Talk us through your typical day

You can find me running around between the Structural Biology laboratories on the fifth floor where I perform biophysical experiments and the Electron Microscopy suite in the basement. I also spend time in the office processing my images to create a 3D molecular structure of my protein of interest.

What big projects are you working on?

HSET is known to help cancer cells evade death. But this protein is completely redundant in healthy cells, making it an important anti-cancer drug target. What’s even more exciting is this protein can literally “hop” within the cell! As a structural biologist, I find that really intriguing to explore.

What’s the best thing about working at the ICR?

A healthy, supportive and professional working environment that allows me to perceive the impact of my research in the big picture of an anti-cancer drug discovery pipeline.

How do you take part in life at the ICR outside your studies?

I am lucky to be working across both the Sutton and the Chelsea sites, so I always have people to hang out with during lunch or after work in a park/pub. Also, the student committee comes up with great ideas for socials to ensure we stay in touch with each other.

What opportunities has studying at the ICR given you?

ICR has given me several opportunities to communicate my science in different ways- to scientific and non-scientific audiences, internal and external talks, oral presentations or written chats.  These challenging experiences have allowed me to grow as a scientific communicator and build a network with professionals in the UK.

What’s your favourite part of life at the ICR?

Meeting and working with people who are as passionate and excited about discussing science as I am.

What do you do to unwind?

I mostly just make music or read comic books. There are some days where I do nothing except browsing through YouTube videos. Before lockdown, I used to play squash in the Sutton site and I hope to do so again soon.

Varun Ramaswamy is a third-year PhD student at the ICR. He is working on a collaborative project between the Division of Cancer Therapeutics and the Division of Structural Biology that aims to solve the 3D structure of a protein called HSET using cryo-electron microscopy and complementary biophysical techniques.

What is your educational/work background?

I did my undergraduate degree in Genetic Engineering at SRM University, India. In 2016, I moved to London to do an MRes in Molecular Biophysics at King’s College London.

Why did you want to study at the ICR?

During my master’s degree, I had the opportunity to work with researchers at the ICR and collect some electron microscopy data. I was really fascinated by the technique and the facility at the ICR and kept in touch with the team about any future research opportunities.

Talk us through your typical day

You can find me running around between the Structural Biology laboratories on the fifth floor where I perform biophysical experiments and the Electron Microscopy suite in the basement. I also spend time in the office processing my images to create a 3D molecular structure of my protein of interest.

What big projects are you working on?

HSET is known to help cancer cells evade death. But this protein is completely redundant in healthy cells, making it an important anti-cancer drug target. What’s even more exciting is this protein can literally “hop” within the cell! As a structural biologist, I find that really intriguing to explore.

What’s the best thing about working at the ICR?

A healthy, supportive and professional working environment that allows me to perceive the impact of my research in the big picture of an anti-cancer drug discovery pipeline.

How do you take part in life at the ICR outside your studies?

I am lucky to be working across both the Sutton and the Chelsea sites, so I always have people to hang out with during lunch or after work in a park/pub. Also, the student committee comes up with great ideas for socials to ensure we stay in touch with each other.

What opportunities has studying at the ICR given you?

ICR has given me several opportunities to communicate my science in different ways- to scientific and non-scientific audiences, internal and external talks, oral presentations or written chats.  These challenging experiences have allowed me to grow as a scientific communicator and build a network with professionals in the UK.

What’s your favourite part of life at the ICR?

Meeting and working with people who are as passionate and excited about discussing science as I am.

What do you do to unwind?

I mostly just make music or read comic books. There are some days where I do nothing except browsing through YouTube videos. Before lockdown, I used to play squash in the Sutton site and I hope to do so again soon.

Lab - View of a lab with scientists working

Support moving to the UK

Whether you're a student or a full time employee, you'll get a variety of social, welfare and accommodation benefits and advice, to help your move to the UK.
Three people sitting at a table in an office, engaged in discussion and collaboration.

Working life and benefits

As a world-leading cancer research organisation, we are a dynamic and exciting place to work - with various benefits and support if you’re moving to the UK.

More about roles at the ICR

Our discoveries are made possible by a mix of scientists at different levels, as well as the leadership and corporate roles that keep us running day to day.

Current openings 

We offer a fantastic working environment, great opportunities for career development and the chance to make a real difference for cancer patients. We aim to recruit and develop the best – with positions for postdocs, scientists and clinicians, and professional or administrative staff - see the latest below:

Postdoctoral Training Fellow - Endocrine Control Mechanisms

  • Chelsea
  • Endocrine Control Mechanisms
  • Salary Range: £45,600 - £55,000 per annum
  • Fixed term

Under the guidance of Professor Cathrin Brisken, we are seeking a highly motivated and ambitious Postdoctoral Training Fellow to combine innovative patient-derived xenograft models and genetic tools to disentangle the role of estrogen and progesterone receptor signaling in breast cancer. The work contributes to gaining more insights into patient-specific hormone dependencies and factors determining them with the aim of personalizing breast cancer therapy and prevention. The successful candidate will be part of a transdisciplinary team of biologists, clinicians and computational scientists and part of close interactions with groups at the ICR, the RMH and King’s College as well Prof. Brisken’s research group at EPFL, Switzerland. About you The successful candidate must have a PhD in biochemistry, pharmacology, cell or molecular biology and demonstrable experience in planning and designing experiments. Ability to write efficient computer code would is desirable. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as a PTDF at the ICR ( this includes experience gained at PDTF level prior to joining the ICR). For general information on Postdocs at The ICR, more information can be found here. Research Group Information Under the leadership of Professor Cathrin Brisken, The Endocrine Control Mechanisms group are using intraductal mammary gland implantation, and ex vivo studies using breast cancers expanded via intraductal implantation. We also use transcriptomic and proteomic studies to investigate therapeutics for breast cancer patients and improve the development of novel treatment options for them. Directorate Information The Breast Cancer Now Toby Robins Research Centre, within the Division of Breast Cancer Research of the Institute of Cancer Research which is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. It is located in state-of-the-art laboratory space, with excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now. The Centre is Directed by Clinician Scientist Professor Andrew Tutt, Professor Chris Lord is Deputy Director of the Centre. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role.

Postdoctoral Training Fellow

  • Chelsea
  • Structural Biology
  • Salary Range: £38,700 - £45,500 per annum
  • Fixed term

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

Group Leader ICR Clinical Trials and Statistics Unit

  • Sutton
  • Clinical Trials Statistics Unit
  • From £66,092
  • Permanent

Under the leadership of Professor Emma Hall, we are seeking to appoint a Research Group Leader to join The CRUK Clinical Trials and Statistics Unit at the ICR. The ICR-CTSU is a research-led, academic trials unit established in the 1980s. The main objective of the ICR-CTSU is to lead the design, conduct and analysis of multi-centre national and international randomised controlled clinical trials of cancer treatments which will directly influence routine clinical practice within the NHS and worldwide. Key Requirements The successful candidate will ideally have: Higher Degree (MSc or PhD) in Medical Statistics or an allied subject. Significant experience as a biostatistician with a research interest in clinical trials methodology. Broad understanding of cancer research Evidence of intellectual leadership (Career Faculty) Ability to generate research funds to support the group. As part of your online application, you will be required to upload your full CV which will pre-populate your application form, you will also be asked to attach the following documents and failure to do so will mean your application cannot be considered on this occasion: Lists of major publications, achievements, research grants and distinctions. Research plan (five to six pages outlining your current research interests and research programme for the next 5 years). The Research plan would be expected to align to ICR-CTSU objectives and include a focus on a methodological area of research which could be applied to the design or analysis of cancer trials. A PDF of a maximum of five key publications, or other research outputs (e.g. patents) that best demonstrate previous productivity or a single document giving hyperlinks to these outputs. You must also complete the personal statement section of the application form in the format of a cover letter including the names and contact details of three academic referees Department/Directorate Information: Division of Clinical Studies Clinical Trials and Statistics Unit (ICR-CTSU) The ICR-CTSU is a Cancer Research UK-funded, internationally recognised methodologist led clinical trials unit, providing cancer-focused clinical trial research expertise. We lead pioneering, efficient, high-quality, and impactful trials across the phases. Our expertise ranges from experimental medicine early phase studies exploring biological efficacy to trials which may deliver widespread change to routine practice, underpinned by applied methodology to drive forward clinical trial innovation. See our clinical trials Joining as a group leader, you will be given outstanding support to help you to continue to develop in your career. Along with a start-up package of funding, you will also have access to resources to establish your group, including support for recruiting key group members, such as PhD students and postdoctoral researchers. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Emma Hall ([email protected])

Higher Scientific Officer - Drug Discovery Biology, Centre for Protein Degradation

  • Sutton
  • Cancer Therapeutics
  • £39,805 - £49,023
  • Fixed term

We are seeking to recruit a Higher Scientific Officer within the Induced Proximity Therapeutics (IPT) Team in the ICR Centre for Protein Degradation to support our molecular glue and PROTAC drug discovery projects and expand induced proximity technology. The IPT team focuses on three main areas of research: Cancer target validation Screening, profiling and molecular mechanism of action of molecular glue and PROTAC degraders Novel E3 ligase biology and ligand discovery The successful candidate will work in a multidisciplinary team and play a key role in target validation, developing in vitro and cell-based assays, and pharmacological characterisation of novel molecular glue degraders and PROTACs, but may also contribute to other activities. About you The successful candidate: Will be a strong team player who is technically minded and passionate about science and cancer drug discovery Will hold a first degree, and preferably a PhD, in biological science or biochemistry Will have experience in cancer biology/target validation, genetic manipulation techniques, in vitro and cell-based assay development and pharmacological compound profiling Experience in targeted protein degradation will be a significant advantage. Department/Directorate Information This position will be based in the ICR's Centre for Protein Degradation, a part of the Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signalling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists, oncology specialists and physicians on discovering new medicines - molecular glue degraders and PROTACs - using innovative screening platforms and characterising their mechanisms of action, as well as expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation). Our research provides a nucleus for the academics and pharmaceutical industry to explore therapeutic potential of targeted protein degradation from laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients. What we offer A dynamic and supportive research environment in one of the successful academic cancer drug discovery centres in the UK Access to state-of-the-art facilities and professional development Collaboration with leading drug discovery and oncology scientist Competitive salary and pension To learn more about this role, please download the attached job pack. For informal inquiries, please contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation via email: [email protected].