Study and Careers

Under the guidance of Professor Cathrin Brisken, we are seeking a highly motivated and ambitious Postdoctoral Training Fellow to combine innovative patient-derived xenograft models and genetic tools to disentangle the role of estrogen and progesterone receptor signaling in breast cancer. The work contributes to gaining more insights into patient-specific hormone dependencies and factors determining them with the aim of personalizing breast cancer therapy and prevention. The successful candidate will be part of a transdisciplinary team of biologists, clinicians and computational scientists and part of close interactions with groups at the ICR, the RMH and King’s College as well Prof. Brisken’s research group at EPFL, Switzerland. About you The successful candidate must have a PhD in biochemistry, pharmacology, cell or molecular biology and demonstrable experience in planning and designing experiments. Ability to write efficient computer code would is desirable. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as a PTDF at the ICR ( this includes experience gained at PDTF level prior to joining the ICR). For general information on Postdocs at The ICR, more information can be found here. Research Group Information Under the leadership of Professor Cathrin Brisken, The Endocrine Control Mechanisms group are using intraductal mammary gland implantation, and ex vivo studies using breast cancers expanded via intraductal implantation. We also use transcriptomic and proteomic studies to investigate therapeutics for breast cancer patients and improve the development of novel treatment options for them. Directorate Information The Breast Cancer Now Toby Robins Research Centre, within the Division of Breast Cancer Research of the Institute of Cancer Research which is the first centre in the UK entirely devoted to breast cancer research. Our goal is to advance research into the causes, diagnosis and treatment of breast cancer. It is located in state-of-the-art laboratory space, with excellent core facilities and is funded through a long term renewable programme grant from Breast Cancer Now. The Centre is Directed by Clinician Scientist Professor Andrew Tutt, Professor Chris Lord is Deputy Director of the Centre. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role.

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on claudio.alfieri@icr.ac.uk

Under the leadership of Professor Emma Hall, we are seeking to appoint a Research Group Leader to join The CRUK Clinical Trials and Statistics Unit at the ICR. The ICR-CTSU is a research-led, academic trials unit established in the 1980s. The main objective of the ICR-CTSU is to lead the design, conduct and analysis of multi-centre national and international randomised controlled clinical trials of cancer treatments which will directly influence routine clinical practice within the NHS and worldwide. Key Requirements The successful candidate will ideally have: Higher Degree (MSc or PhD) in Medical Statistics or an allied subject. Significant experience as a biostatistician with a research interest in clinical trials methodology. Broad understanding of cancer research Evidence of intellectual leadership (Career Faculty) Ability to generate research funds to support the group. As part of your online application, you will be required to upload your full CV which will pre-populate your application form, you will also be asked to attach the following documents and failure to do so will mean your application cannot be considered on this occasion: Lists of major publications, achievements, research grants and distinctions. Research plan (five to six pages outlining your current research interests and research programme for the next 5 years). The Research plan would be expected to align to ICR-CTSU objectives and include a focus on a methodological area of research which could be applied to the design or analysis of cancer trials. A PDF of a maximum of five key publications, or other research outputs (e.g. patents) that best demonstrate previous productivity or a single document giving hyperlinks to these outputs. You must also complete the personal statement section of the application form in the format of a cover letter including the names and contact details of three academic referees Department/Directorate Information: Division of Clinical Studies Clinical Trials and Statistics Unit (ICR-CTSU) The ICR-CTSU is a Cancer Research UK-funded, internationally recognised methodologist led clinical trials unit, providing cancer-focused clinical trial research expertise. We lead pioneering, efficient, high-quality, and impactful trials across the phases. Our expertise ranges from experimental medicine early phase studies exploring biological efficacy to trials which may deliver widespread change to routine practice, underpinned by applied methodology to drive forward clinical trial innovation. See our clinical trials Joining as a group leader, you will be given outstanding support to help you to continue to develop in your career. Along with a start-up package of funding, you will also have access to resources to establish your group, including support for recruiting key group members, such as PhD students and postdoctoral researchers. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Emma Hall (Emma.Hall@icr.ac.uk)

Professor Johann de Bono’s translational research team is seeking a talented Postdoctoral Training Fellow. The programme focuses on integrating multi-omic and clinical data, including single cell and spatial data as well as hyperplex immunocytochemical data, to help develop novel therapeutic strategies against cancer. For general information on Post Docs at The ICR can be found here. Key Requirements The successful candidate will be highly motivated and possess robust bioinformatic, scientific, and analytical skills, with a proactive approach to learning and applying new techniques, including artificial intelligence. Primary responsibilities will involve working with integrated datasets including clinical trial datasets comprising next-generation sequencing data and other applications relevant to the analysis of DNA and RNA sequencing, as well as protein assays. Familiarity with cancer genomics is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as a PTDF at the ICR ( this includes experience gained at PDTF level prior to joining the ICR). Department/Directorate Information: Professor Johann de Bono is a world leader in anticancer drug development, biomarker studies, and prostate cancer care. His team conducts biomarker-driven clinical and translational research to accelerate the development of novel cancer therapies and improve understanding of cancer biology, drug sensitivity and resistance. His team has driven major advances in cancer care through early and late stage trials, and he has led pivotal phase III trials of several prostate cancer drugs including abiraterone, cabazitaxel, enzalutamide, lutetium PSMA and olaparib. His team consists of basic, translational and clinical scientists, and is embedded in a vibrant world-class research environment. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Wei Yuan via email on wei.yuan@icr.ac.uk Due to the high volumes of applications that we receive, we reserve the right to close the advert before the published closing date, once we have received a sufficient number of applications. Therefore, we advise that you to submit your application, as early as possible to avoid disappointment.