Study and Careers

Under the leadership of Claudio Alfieri, we are seeking to appoint a Postdoctoral Training Fellow to join the Molecular Mechanisms of Cell Cycle Regulation Group at the Chester Beatty Laboratories, Fulham Road in London. This project aims to investigate the molecular mechanisms of cell cycle regulation by macromolecular complexes involved in cell proliferation decisions, by combining genome engineering, proteomics and in situ structural biology. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD in cellular biochemistry and experience in Cryo-EM and CLEM is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years Department/Directorate Information: The candidate will work in the Molecular Mechanisms of Cell Cycle Regulation Group within the ICR Division of Structural Biology headed by Prof. Laurence Pearl and Prof. Sebastian Guettler. The division has state-of-the-art facilities for protein expression and biophysics/x-ray crystallography, in particular the Electron Microscopy Facility is equipped with a Glacios 200kV with Falcon 4i detector with Selectris energy filter and the ICR has access to Krios microscopes via eBIC and the LonCEM consortium. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Claudio Alfieri via Email on [email protected]

We are seeking to recruit a Higher Scientific Officer within the Induced Proximity Therapeutics (IPT) Team in the ICR Centre for Protein Degradation to support our molecular glue and PROTAC drug discovery projects and expand induced proximity technology. The IPT team focuses on three main areas of research: Cancer target validation Screening, profiling and molecular mechanism of action of molecular glue and PROTAC degraders Novel E3 ligase biology and ligand discovery The successful candidate will work in a multidisciplinary team and play a key role in target validation, developing in vitro and cell-based assays, and pharmacological characterisation of novel molecular glue degraders and PROTACs, but may also contribute to other activities. About you The successful candidate: Will be a strong team player who is technically minded and passionate about science and cancer drug discovery Will hold a first degree, and preferably a PhD, in biological science or biochemistry Will have experience in cancer biology/target validation, genetic manipulation techniques, in vitro and cell-based assay development and pharmacological compound profiling Experience in targeted protein degradation will be a significant advantage. Department/Directorate Information This position will be based in the ICR's Centre for Protein Degradation, a part of the Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signalling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists, oncology specialists and physicians on discovering new medicines - molecular glue degraders and PROTACs - using innovative screening platforms and characterising their mechanisms of action, as well as expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation). Our research provides a nucleus for the academics and pharmaceutical industry to explore therapeutic potential of targeted protein degradation from laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients. What we offer A dynamic and supportive research environment in one of the successful academic cancer drug discovery centres in the UK Access to state-of-the-art facilities and professional development Collaboration with leading drug discovery and oncology scientist Competitive salary and pension To learn more about this role, please download the attached job pack. For informal inquiries, please contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation via email: [email protected].

We are looking to appoint an experienced and committed Clinical Trial Programme Manager to work within the Drug Development Unit (DDU) at the ICR and RM. The Unit delivers industry/academic -sponsored early phase clinical trials of new anticancer drugs. The DDU is one of the leading clinical trial units in the world that undertakes early-phase oncology trials for solid tumours. Over the years, DDU has played a significant role in transitioning several anti-cancer drugs from bench -to-bedside, many of which have now become standard of care cancer treatments. The Unit has a dedicated ward within the Royal Marsden Hospital for the development of novel cancer therapeutics, which we believe will improve the care of cancer patients. Key Requirements The post holder will be educated to at least degree level in life sciences or a health related area, with previous experience of managing and working in clinical trials with an excellent understanding of the conduct of Phase I oncology trials. They must be able to manage a team of skilled people and several complex studies at a time. The post holder will be key to the communication and operations with the unit’s management group, clinical study team and with external partners, ensuring that studies are run to protocol and in accordance with ICH-GCP. The post holder must be highly organised and able to plan work around a busy clinical unit. They should have excellent communication and interpersonal skills in order to interact effectively with unit staff and patients. Institution Information The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer. The Royal Marsden NHS Foundation Trust is a world-leading specialist cancer hospital. The Institute of Cancer Research works in close partnership with The Royal Marsden to take the results of our research rapidly into the clinic, with the aim of developing better treatments for cancer patients. Department/Directorate Information The ICR and The Royal Marsden are internationally renowned for our work together to conduct early- and late-phase clinical trials. Our joint Drug Development Unit, which sees around 300 patients per year, is one of the largest centres for phase I trials in the world and makes an important contribution to the worldwide effort to discover and develop new cancer drugs. The Drug Development Unit, is led by Professor Johann de Bono, comprises of clinicians, scientists, data and study management staff, and focuses on providing a seamless conduit between pre-clinical drug discovery, proof of principle Phase-1 clinical trials and tumour specific evaluation of novel agents. The Unit undertakes both industry-sponsored and investigator-initiated trials of new anti-cancer drugs. The Unit is rapidly expanding and provides an excellent opportunity for the post holder to develop a variety of skillsets. This post also benefits from generous annual leave entitlement and a pension. To apply for this post, please submit an online application including a supporting statement, detailing reasons why you are applying for the post and with your CV. We encourage all applicants to access the job pack attached for more detailed information regarding this role. Due to the high volumes of applications we receive, we reserve the right to close the advert before the published closing date once we have received a sufficient number of applications. Therefore we advise that you to submit your application, as early as possible to avoid disappointment.

About the Role We are seeking a Learning and Development Programme Coordinator to join our department and contribute to all aspects of the scheduling, delivery and evaluation of the ICR’s training offer for staff and students and supporting the implementation of our new learning management system. The successful candidate will play a key role in liaising with internal and external trainers to coordinate our annual programme of training and events, managing training budgets, producing training reports and evaluations and project managing the move to a new learning management system. Key Responsibilities Project managing the implementation of a new learning management system (LMS) Training programme management and scheduling Liaising with internal and external training providers Evaluating the annual training programme Managing the resource bank of on demand training About You We are looking for a self-motivated individual who is highly organised and can work to tight deadlines. The ideal candidate will have a Degree level qualification in Business, Communication, HR or equivalent experience. Proven experience in managing the delivery of a structured programme of events. Significant experience of implementing LearnUpon or other Learning Management System. Excellent organizational and time-management skills. Good commercial awareness and experience of dealing directly with suppliers. Strong communication and interpersonal abilities. Proficiency in Microsoft Office, Learn Upon/other LMS. What We Offer A supportive and collaborative working environment. Opportunities for professional development and career progression. Competitive salary and pension Department/Directorate Information The Learning and Organisation Team are part of the HR Directorate and provide a wide range of training and career development support for all staff and students covering: research skills, management and leadership development and personal development. We also lead on supporting equality and diversity including external awards such as Athena SWAN and HR Excellence in Research. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact [email protected].