Radiotherapy Physics Modelling Group
Professor Uwe Oelfke’s group is researching ways of using modern hardware to improve the delivery of targeted radiotherapy.
Our group aims to improve the accuracy of the Radiotherapy process by investigating the uncertainties involved in the different steps throughout the treatment chain, starting at the imaging stage right through to the actual delivery process.
The Radiotherapy Physics Modelling group aims to improve the accuracy of the Radiotherapy process by investigating the uncertainties involved in the different steps throughout the treatment chain, starting at the imaging stage right through to the actual delivery process.
One important step is the better integration of multi-modality imaging into the treatment planning process not only for the target delineation process but also for monitoring tumour response. We aim to quantify these effects by modelling the tumour response to radiation within preclinical systems as well as for patients treated within clinical trials. Using functional images like PET or fMRI during the treatment planning process will help us to reduce the uncertainties involved within the definition of the tumour volume.
Modelling the biological uncertainties within the treatment planning system enables us to create treatment plans which are not only robust with respect to tumour motion but also to the biological input parameters. Some of these techniques are based on our ultra-fast treatment planning framework which we developed as an important step towards fully automated treatment planning as well as interactive real-time adaptation of treatment plans to the current anatomical situation.
In addition to adaptive and image guided treatment planning we are also actively developing methods to reduce the geometric uncertainties present during the delivery of radiation therapy by implementing active motion mitigation technics like gating or multi-leaf collimator tracking methods.
We are also investigating the physical and biological properties of the application of alternative treatment techniques like Micro-beam irradiation or particle therapy in combination with the existing treatment methods.
Professor Uwe Oelfke
Deputy Head of Division:
Radiotherapy Physics Modelling
Professor Uwe Oelfke is combining recent developments in cancer biology, cancer therapeutics and medical physics in order to improve radiotherapy treatment and planning. He has had a varied career spanning theoretical nuclear physics and finally medical physics.
Researchers in this group
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Email: [email protected]
Location: Sutton
Working in the Centre for Cancer Imaging (CCI), I facilitate biological experiments for scientists (usually with a non-biological background) who are developing imaging biomarkers to monitor treatment response. Particular interests include tumour hypoxia and molecular mechanisms of therapy resistance. As the Deputy CCI Lab Manager I also contribute to the efficient operation of the CCI’s research facilities.
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Email: [email protected]
Location: Sutton
I work jointly at the Royal Marsden Hospital and the ICR as a radiotherapy physicist with an interest in adaptive radiotherapy techniques. I have worked on the clinical implementation of the Elekta Unity MR-linac at the RMH with a focus on adaptive re-planning strategies and workflows.
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Email: [email protected]
Location: Sutton
I am a Clinical Scientist in the MR Linac Group at the Royal Marsden Hospital. I am currently undertaking a PhD investigating dose reconstruction methods for dynamic tumour tracked and online adapted treatments on the MR Linac.
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I am a Postdoctoral Training Fellow working on distortion-less diffusion-weighted MRI for the Unity MR-Linac system. Another research interest to me is characterization of intravoxel incoherent motion with tailored diffusion-weighting gradient profiles. To achieve this, I use MR pulse programming, which I learned during my PhD on MR Neurography.
Professor Uwe Oelfke's group have written 49 publications
Most recent new publication 7/6/2013
See all their publications
