Cancer Genomics Group
Our group is interested in using genetic approaches to understand underlying susceptibility and pathogenesis of human malignancies.
Research, projects and publications in this group
The Houlston Group has a primary interest in using genetic approaches to understand a genetic background underlying susceptibility and pathogenesis of human malignancies.
The research of the group focuses on the following strands:
- Susceptibility gene identification in cancer using large-scale genetic and genomic approaches. We are involved in the major international efforts exploiting large-scale genome wide association and next-generation sequencing efforts to map variants impacting on cancer predisposition
- Translating gene identification into biological insights and clinical advances. We use complementary approaches involving human, animal models and cellular systems to define the biological and clinical consequences of discoveries.
- Genomic epidemiology. Integrating genetic and other data to advance understanding of basic genomic processes.
- Statistical genetics and bioinformatics. Implementation of new approaches to tackle associated analytical challenges.
- Our recent research has made a major contribution to advances in the understanding of the genetic basis of cancer and our work has featured in over 50 papers published in Nature Genetics, Nature and Science.
Professor Richard Houlston
Head of Division:
Cancer Genomics
Professor Richard Houlston is Head of the Division of Genetics and Epidemiology. His research focuses on the identification and characterisation of genetic susceptibility to cancer.
Researchers in this group
.
.
I come from a PhD background in applied statistics, with knowledge of both frequentist and Bayesian statistics, and our group is using a variety of methods to understand how the incidence of colorectal cancer is affected by both genetic and environmental variables. In particular, I hope to improve my skills in bioinformatics and systems biology within the application of cancer.
.
Dr Andrea Gunnell is a cell biologist working on the identification of new predisposition alleles for myeloma through GWAS analysis and molecular genetic functional studies to elucidate biological basis for genetic susceptibility.
.
Dr Sureyya Kose recently earned her PhD in Chemistry, investigating the interaction between microbial gene expression and host innate immunity to reveal processes that may lead to cholelithiasis. Presently, her work involves the identification of genetic susceptibility to childhood cancer.
.
OrcID: 0000-0001-9300-3822
Email: [email protected]
Also on: shalini-singh-0238b3127
Location: Sutton
I am currently investigating the molecular mechanism of drug resistance in multiple myeloma using molecular and cell biology techniques.
.
Dr Jayaram Vijayakrishnan is a molecular geneticist investigating genetic predisposition to cancer. His work involves the use of molecular and cell biology techniques and subsequent bioinformatic analysis of data.
.
I'm in the first year of my postdoc after finishing my PhD in the Houlston Lab. I’m investigating inherited predisposition to multiple myeloma. My work involves the identification and characterisation of germline risk variants for myeloma with a view to improve our understanding of pathways relevant to the disease.
Professor Richard Houlston's group have written 50 publications
Most recent new publication 4/3/2010
See all their publications