Paediatric Solid Tumour Biology and Therapeutics Group

Under the leadership of Dr Olivia Rossanese, we are seeking to appoint a Team Leader to join The Centre for Cancer Drug Discovery (CCDD) as The Head of Biology and Director of the Centre for Target Validation. Key Requirements The successful candidate must have in-depth knowledge and recent experience in an area of cancer biology relevant to oncology drug discovery. Leadership experience of drug discovery within, or in collaboration with, the pharmaceutical or biotechnology industry as evidenced by publication and/or successful commercial projects. Along with completing the online application form, you will be asked to attach the following documents and failure to do so will mean your application cannot be considered on this occasion: · Full CV · Lists of major publications, achievements, research grants, distinctions. · A PDF of a maximum of five key publications, or other research outputs (e.g. patents) that best demonstrate previous productivity · You must also complete the personal statement section of the application form in the format of a covering letter including the names and contact details of three academic referees Department/Directorate Information: The Division of Cancer Therapeutic's mission is to develop personalised medicines by translating information from the cancer genome and cancer biology into drugs for patient benefit. We implement innovative drug discovery technologies, discover novel mechanism-based drugs, and develop these as rapidly as possible from the laboratory through to hypothesis-testing early clinical trials We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Olivia Rossanese, Email [email protected]

Under the leadership of Dr. Jörg Mansfeld, we are seeking a highly motivated and ambitious candidate for a Postdoctoral Training Fellow position, with experience in cell cycle research, ubiquitin, or redox biology. This position will build on our recent work on CDK2 and p21 oxidation, as well as cell cycle-dependent redox proteomics, to investigate the interplay between protein oxidation, ubiquitinylation, and phosphorylation in both non-transformed and cancer cells. We collaborate with several groups at the ICR to validate our findings in animal models and patient samples. The successful candidate will have the intellectual freedom to develop the project, with support from the Group Leader, while working as part of a collaborative and multidisciplinary team. More information can be found in the Job Description Pack (see download link to the right). For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have previous experience in cell cycle, ubiquitin, or redox research. A strong cell biology or biochemistry background with an emphasis on the regulation of protein-protein interactions and mechanistic studies in vitro or in cells is highly desirable. Knowledge in DNA replication and/or DNA damage repair is desirable. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years. Post-translational Modifications and Proliferation Group The Post-translational Modifications and Proliferation Group investigates the intricate regulation of cell cycle control through post-translational modifications (PTMs). We focus on the interplay of thiol oxidation with phosphorylation and ubiquitylation in the context of cell cycle regulation. We employ cutting-edge mass spectrometry to identify PTMs, advanced gene-editing, and single-cell imaging to investigate the physiological impact of PTMs. Experimental models include 2D and 3D cell culture with a focus on non-transformed cell models and breast cancer. More information about our work can be found at www.mansfeldlab.com. Our team is embedded within the Cancer Biology Division at the ICR’s Chester Beatty Laboratories in Chelsea, London. We have a highly supportive and interactive research environment, and state of the art facilities for cell biology, molecular biology, next-generation sequencing and structural biology. We also closely interact with other divisions at the ICR, including Breast Cancer Research, Radiotherapy and Imaging, and Structural Biology. The great variety of disciplines at the ICR will ensure that the successful candidate will be exposed to fantastic research and seminars from all types of backgrounds. Download the job pack for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr. Jörg Mansfeld via email: [email protected].