Cancer Stem Cell Group

Professor Axel Behrens' group uses a combination of sophisticated genetics and human cancer organoids to understand the biology of cancer and to develop novel therapeutic options, with an emphasis on breast cancer and pancreatic cancer.

Research, projects and publications in this group

We have made significant contributions to cancer cell biology in the last few years, including developing a 3D imaging technology termed FLASH, which opened a novel field of experimental 3D tumour imaging. We will use FLASH in various aspects of our future work.

Professor Axel Behrens

Group Leader:

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Professor Axel Behrens is a well-known international expert in cancer stem cell biology as well as a pioneer in forging partnerships between scientists from different disciplines. He leads the Cancer Stem Cell Group at the ICR in parallel with heading up the Cancer Research UK Convergence Science Centre, a major strategic collaboration between the ICR and Imperial College London.

Researchers in this group

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Phone: +44 20 7153 5566

Email: [email protected]

Location: Chelsea

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Phone: +44 20 3437 6070

Email: [email protected]

Location: SuttonChelsea

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Phone: +44 20 3437 6067

Email: [email protected]

Location: Chelsea

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Phone: +44 20 3437 6205

Email: [email protected]

Location: Chelsea

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Email: [email protected]

Location: Chelsea

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Phone: +44 20 3437 6065

Email: [email protected]

Location: Chelsea

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Phone: +44 20 7153 5523

Email: [email protected]

Location: Chelsea

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Phone: +44 20 7153 5575

Email: [email protected]

Location: Chelsea

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Phone: +44 20 3437 6238

Email: [email protected]

Location: Chelsea

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Phone: +44 20 7153 5402

Email: [email protected]

Location: Chelsea

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Email: [email protected]

Location: Chelsea

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Email: [email protected]

Location: Chelsea

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Phone: +44 20 7153 5353

Email: [email protected]

Location: Chelsea

Professor Axel Behrens's group have written 87 publications

Most recent new publication 7/2024

See all their publications

It has become clear that tumours are organised in a cellular hierarchy, with the so-called cancer stem cells (CSC), also called Tumour initiating cells (TICs), being at the apex. It is believed that CSCs mediate tumour growth, precipitate tumour relapse after treatment, and are responsible for metastasis formation. Therefore understanding the molecular mechanisms underlying CSC function may lead to novel therapeutic approaches.

In the last years we made significant contributions to cancer cell biology. We identified a CSC population for luminal breast cancer marked by Lgr6 (Blaas et al., Nature Cell Biology, 2016). Remarkably, Lgr6-posititve CSCs are required to maintain the cellular heterogeneity and malignancy of luminal breast cancer, suggesting that the cellular diversity of luminal breast cancer is generated by CSC, conceptually similar to the function of stem cells in normal organs. In addition, we shed light on the cell of origin and mechanisms of pancreatic adenocarcinoma (PDAC) development (Gruber et al., Gastroenterology, 2016; Ferreira et al. Cell Reports, 2017), and characterised a CD9-positive CSC population in PDAC which is essential for PDAC ontogenesis (Wang et al., Nature Cell Biology, 2019).

Moreover, we developed a 3D imaging technology termed FLASH that provides unprecedented capabilities to visualise large tissues at single cell resolution. FLASH opened a novel field of experimental 3D tumour imaging, and we used FLASH to obtain fundamental insights into pancreatic tumourigenesis (Messal et al., Nature, 2019). Future work will focus on using FLASH to characterise tumour development and relapse, understanding the molecular mechanism underlying CSC function, and to identify CSC vulnerabilities which can be therapeutically exploited.

Recent discoveries from this group

21/05/24

Axel Behrens, Scientific Director of the Convergence Science Centre

Image: Axel Behrens, Scientific Director of the Convergence Science Centre.

Professor Axel Behrens, Scientific Director of the Cancer Research UK Convergence Science Centre and leader of the Cancer Stem Cell Group at The Institute of Cancer Research, London, has been awarded a prestigious Fellowship by the Academy of Medical Sciences.

Each year, the Academy Fellowship recognises scientists who have made outstanding contributions to medicine and society through their research in a range of scientific fields. Professor Behrens joins 58 other biomedical and health researchers across the UK who have been elected as Fellows based on their demonstration of scientific excellence and ability to advance understanding and improve public health around the world.

Professor Behrens is a well-known international expert in cancer stem cell biology. Standout publications from his group have shed new light on mechanisms of tumour progression in pancreatic cancer, and they have discovered a rare population of progenitor cells that can originate luminal breast cancers.

Empowering convergence science at the ICR

Professor Behrens joined The Institute of Cancer Research (ICR) in 2020 as the inaugural Scientific Director of the Cancer Research UK Convergence Science Centre, a major strategic partnership between the ICR and Imperial College London. The centre brings together scientists from different disciplines to tackle research questions in new ways – by forging partnerships between biologists and scientists in other fields, including engineering, physics, and mathematical modelling.

After completing his PhD in Austria, Professor Behrens carried out his postdoctoral studies in Switzerland, before setting up a laboratory at the Cancer Research UK London Research Institute (now part of The Francis Crick Institute) in 2001.

His achievements have been recognised by membership of the European Molecular Biology Organization (EMBO) and the Academia Europaea, and by honorary professorships from King’s College London (UK) and Sun-Yat-Sen University (China).

Recognising multidisciplinary working in cancer research

Professor Axel Behrens, Scientific Director of the CRUK Convergence Science Centre and Professor of Stem Cell Biology within the Breast Cancer Now Toby Robins Research Centre at the ICR, said:

"I am delighted to be elected as a Fellow of the Academy of Medical Sciences. This honour recognises the importance stem cell biology and of multidisciplinary working in cancer research which is critical to tackling unresolved problems in cancer biology and bringing innovative treatments to patients more quickly.”

Professor Kristian Helin, Chief Executive of the ICR, said:

“This prestigious award recognises scientists who have made outstanding contributions to medicine and society through their research. We are extremely proud to see Professor Axel Behrens receive it. We are delighted that The Institute of Cancer Research is continuing its involvement with the Academy of Medical Sciences and working together to further our understanding of the complex health issues we are facing globally.”

Professor Deborah Ashby, Dean of the Faculty of Medicine at Imperial College London, said:

“I’m so very pleased to see how many of Imperial’s health and science researchers have been recognised by the Academy for their tireless work and we’re proud to see all of them achieve this significant milestone in their careers. Each one of these new Fellows carries out important research - often with global resonance and impact.”

Professor Behrens will be formally admitted to the Academy as a Fellow on 18 September 2024.