Dr Isaline Castan

Isaline joined the ICR in September 2024 as a Postdoctoral Training Fellow. She completed her master’s in chemical process engineering at CPE Lyon, France with an Erasmus year at University College of London (UCL), UK in Medicinal chemistry. She worked as a Medicinal chemist in the CDoT at the Broad Institute of MIT and Harvard focusing on hit-to-lead optimisation. She then completed her Ph.D. in Medicinal chemistry in collaboration with AstraZeneca under the supervision of Prof. Mike Waring, her research focused on expanding the scope of chemical reactions for the synthesis of DNA-encoded libraries. She went on joining the DEL synthesis team as a Senior research scientist in AstraZeneca, Sweden for a year where she focused on innovative approaches to DNA-encoded chemistries and hit finding strategies. She is now working with Prof. Swen Hoelder on the design and synthesis of selective PROTACs as anticancer agents.