Data Science at the ICR
From mapping the paths of cancer evolution, to the design and discovery of novel drugs - we are leading in innovative cancer informatics.
Cancer is a complex, ever-changing set of diseases, and new technologies allow us to gather data to get a comprehensive view of cancer's various facets. As a result, computational research and data science are at the forefront in our battle against cancer.
Informatics research at the ICR spans a range of fields, including
- bioinformatics and computational biology
- biostatistics
- mathematical biology
- in-silico medicinal chemistry
- digital pathology
- and computational physics.
Tools and Resources
To empower cancer research across the international community, the ICR provides public access to many of our unique tools and resources.
Research platforms, knowledgebases and databases
CanSAR
The world’s largest public resource for cancer drug discovery and translational research. Includes a comprehensive, weekly updated target druggabilitry assessment.
CanSARS
CanSARS is the Coronavirus research view of canSAR. We provide it freely and openly to the research and drug discovery community to support them in the battle against Covid-19 and other coronaviruses.
Switches.ELM
A database that curates experimentally validated motif-based molecular switches and a prediction tool to identify possible switching mechanisms that might regulate a user-submitted motif of interest.
Chemical Probes
A portal providing expert guidance and reviews of chemical probes for use in biological research. The gold reference for chemical probes.
Probe Miner
A large-scale, statistical, objective assessment of small molecules for use as chemical probes.
Articles.ELM
A resource that simplifies access to protein linear motif literature by annotation, text-mining and classification.
Web-based tools
ProViz
ProViz (Protein Vizualisation) is an interactive exploration tool for investigating the functional and evolutionary features of proteins.
LocusExplorer
An interactive graphical illustration of genetic associations and their biological context.
PSSMSearch
PSSMSearch is a web application to discover novel protein motifs (SLiMs, mORFs, miniMotifs) and PTM sites.
Tools and resources for download
PhenoPlot is a novel visualisation method that simulates various aspects of cellular structures to represent imaging data in a concise and a quantitative way.
A multipoint linkage analysis of densely distributed SNP data incorporating automated linkage disequilibrium removal.
A database of the Predicted Impact of Coding SNPs on protein function in genes relevant to the biology of cancer.