Study and Careers

Under the leadership of Dr Olivia Rossanese, we are seeking to appoint a Team Leader to join The Centre for Cancer Drug Discovery (CCDD) as The Head of Biology and Director of the Centre for Target Validation. Key Requirements The successful candidate must have in-depth knowledge and recent experience in an area of cancer biology relevant to oncology drug discovery. Leadership experience of drug discovery within, or in collaboration with, the pharmaceutical or biotechnology industry as evidenced by publication and/or successful commercial projects. Along with completing the online application form, you will be asked to attach the following documents and failure to do so will mean your application cannot be considered on this occasion: · Full CV · Lists of major publications, achievements, research grants, distinctions. · A PDF of a maximum of five key publications, or other research outputs (e.g. patents) that best demonstrate previous productivity · You must also complete the personal statement section of the application form in the format of a covering letter including the names and contact details of three academic referees Department/Directorate Information: The Division of Cancer Therapeutic's mission is to develop personalised medicines by translating information from the cancer genome and cancer biology into drugs for patient benefit. We implement innovative drug discovery technologies, discover novel mechanism-based drugs, and develop these as rapidly as possible from the laboratory through to hypothesis-testing early clinical trials We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Olivia Rossanese, Email [email protected]

Under the leadership of Prof. Jessica Downs, we are seeking to a highly motivated individual to join the Epigenetics and Genome Stability Team as Scientific Officer. The ideal candidate will be responsible for the day-to-day running of the lab, maintain general lab equipment and perform experiments and contribute to ongoing research projects using basic cell and molecular biology approaches, including tissue culture, microscopy, and viability assays. Key Requirements The successful candidate must have strong organisational skills, be able to work collaboratively, take initiative and work precisely with excellent attention to detail and produce reproducible results. Experience with microscopy, genetic engineering, viability assays, PCR, cloning, or protein purification, and coding skills are highly desirable. Epigenetics and Genome StabilityTeam The Epigenetics and Genome Stability Team (thedownslab.org) studies the role of chromatin and epigenetic regulation in maintaining genome stability. The goal of this research is to understand how the packaging and organisation of DNA helps to maintain its integrity and prevent Tumourigenesis. We are also exploring how these insights can help identify new therapeutic approaches. Our team is embedded within the Cancer Biology Division at the ICR’s Chester Beatty Laboratories in Chelsea, London. We have a highly supportive and interactive research environment, and state of the art facilities for cell biology, molecular biology, next-generation sequencing and structural biology. We also closely interact with other divisions at the ICR, including Breast Cancer Research, Radiotherapy and Imaging, and Structural Biology. The great variety of disciplines at the ICR will ensure that the successful candidate will be exposed to fantastic research and seminars from all types of backgrounds. Download the job pack for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Jessica Downs via email:[email protected]

Under the leadership of Professor Vlad Pena, we are seeking to appoint a Postdoctoral Training Fellow with a strong interest in the structural biology of RNA-protein complexes. The primary objective of this project is to elucidate how RNA splicing is regulated by a specific set of chromatin factors. The successful candidate will focus on reconstituting spliceosomes involved in this process and determining their structures using cryo-electron microscopy (cryo-EM). Comprehensive training in specialized techniques will be provided. Our laboratory offers regular access to cutting-edge structural biology facilities, including recombinant protein expression, purification systems, mammalian cell bioreactors, advanced electron microscopy (Glacios and Titan Krios), high-performance GPU computing clusters, mass spectrometry, and both preparative and analytical biochemistry tools. More detailed information about our research can be found on our webpage. For general information on Post Doc's at The ICR can be found here. Key Requirements The successful candidate must have a PhD (or equivalent) in structural biology and demonstrate strong expertise in the biochemistry of macromolecular complexes. While experience in RNA biology, the structural study of RNA-protein complexes, and cryo-EM is advantageous, we encourage applications from all talented scientists with a passion for this field. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years Department/Directorate Information: The Division of Structural Biology is located at the ICR site in the picturesque Chelsea district of London, offering a vibrant scientific and cultural atmosphere and excellent opportunities for both personal and professional growth. We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Prof Vlad Pena at [email protected]

Under the leadership of Professor Johann de Bono, we are seeking to appoint a Biological Specimen Coordinator to join The Drug Development Unit (DDU), within the ICR and Royal Marsden. DDU undertakes industry-sponsored early phase clinical trials of new anticancer drugs. We are a world class clinical trials unit with a dedicated ward within the Royal Marsden Hospital for the development of novel cancer therapeutics which we believe will improve the care of cancer patients. Key Requirements The successful candidate must have a BSc. in biomedical sciences or equivalent and possess strong computer skills. Experience with range of laboratory molecularly biology techniques, knowledge of FFPE samples and circulating plasma DNA and experience handling clinical samples are desirable. The post holder will work within the Institute of Cancer Research (ICR) and will have close interaction with staff from Royal Marsden NHS Foundation Trust (RM) Tissue Collection Facility. The post holder will be responsible for collecting, cataloguing and processing clinical samples (usually tumour and blood specimens). The post holder will be responsible for developing, implementing and reviewing tracking systems for all tissue samples coming through the unit and will ensure all procedures meet with Human Tissue Act (HTA) requirements and Good Clinical Practice UK Regulations for hosted commercial/academic studies as well as all tissue retrieved for central review from all participating centres in the UK and globally for studies running through the Drug Development. Our Biological Specimen Coordinator post is predominantly based on our Sutton site, but occasionally the post holder will occasionally need to travel to our Chelsea site for biopsy tissue collection. The appointment will be on a fixed term contract for one year in the first instance. This post also benefits from generous annual leave entitlement and a pension. To apply for this post, please submit an online application including a supporting statement, detailing reasons why you are applying for the post and with your CV. We encourage all applicants to access the job pack attached for more detailed information regarding this role. Due to the high volumes of applications we receive, we reserve the right to close the advert before the published closing date once we have received a sufficient number of applications. Therefore we advise that you to submit your application, as early as possible to avoid disappointment. Department/Directorate Information The Drug Development Unit is led by Professor Johann de Bono, comprises of clinicians, scientists, data and study management staff, and focuses on providing a seamless conduit between pre-clinical drug discovery, proof of principle Phase-1 clinical trials and tumour specific evaluation of novel agents. The Unit undertakes both industry-sponsored and investigator-initiated trials of new anti-cancer drugs. The Unit is rapidly expanding and provides an excellent opportunity for the post holder to develop a variety of skillsets.