Our research into breast cancer

Our scientists have been involved in some of the most famous discoveries in breast cancer research, leading studies that have transformed treatment for breast cancer on a global scale.

Meet our researchers

When I was diagnosed with breast cancer, my world fell apart – so it was a no-brainer for me to have preventative surgery when I discovered I had the BRCA2 gene mutation.

It’s very reassuring to know that cancer research is leading to more advances in diagnosis and treatment, and I’m so thankful that by the time my children are grown up, they will hopefully have more options.

– Caroline Wheeldon

Caroline has her arm around her daughter Aleisha, both sitting on a sofa

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Our progress against breast cancer

Identifying the BRCA2 gene

We made one of the most significant discoveries in cancer genetics to date – identifying the BRCA2 gene. The discovery of this gene has helped thousands of people with a family history of breast cancer get tested and assess their risk of developing the disease.

Developing new drugs

Alongside our partner hospital, The Royal Marsden, we played a leading role in the development of a class of drugs called aromatase inhibitors, now commonly used to treat breast cancer in post-menopausal women.

Our research underpinned the development of drugs called PARP inhibitors, one of which is olaparib, now used in the treatment of breast and ovarian cancer in patients with mutations in their BRCA genes.

Clinical trials

We led trials establishing the effectiveness of the chemotherapy drug carboplatin – discovered at the ICR – in triple-negative breast cancer, and of the targeted drug palbociclib in advanced, metastatic breast cancer.

Recently, results from the OlympiA trial showed that using the targeted drug olaparib to treat some women with early stage breast cancer and mutations in their BRCA genes reduced their risk of breast cancer coming back by 42 per cent.

Better tests

We are developing new tests to detect breast cancer and predict which patients are likely to see their disease come back, and spread.

For example, we pioneered the development of ‘liquid biopsies’ – blood tests that can detect the spread of cancer more quickly.

Recent results from the PlasmaMATCH trial have shown that liquid biopsies can match women with breast cancer to targeted drugs based on their specific mutations.

Radiotherapy

We have transformed radiotherapy treatment for breast cancer.

Together with The Royal Marsden, we led the START trial, which showed that women could safely undergo fewer, larger doses of chemotherapy with reduced side effects, reducing standard treatment from 25 doses over five weeks, to 15 doses over three weeks.

More recently, the FAST-Forward trial showed that the course could be further reduced to just one week, with the same benefits, for women with early-stage breast cancer.

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