Structure-based drug design of cancer drugs

• Inhibitors of monopolar spindle 1 (MPS1) kinase
• Inhibitors of the KDM4/5 JmJC histone demethylases
• AGC kinase inhibitors

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Fragment-based lead discovery

• Fragment screening of Checkpoint kinase 2
• A fragment-based approach to target HSP70

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Assay development and screening

• Identification of IRE1 inhibitors

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