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Begg, K.A. Braun, H. Ghaddar, N. Wu, L. Downs, J.A. (2024). Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses. Dna repair, Vol.133, pp. 103609-103609.  full text

Schiavoni, F. Zuazua-Villar, P. Roumeliotis, T.I. Benstead-Hume, G. Pardo, M. Pearl, F.M. Choudhary, J.S. Downs, J.A. (2022). Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness. Nat commun, Vol.13 (1), p. 1731.  show abstract  full text

Feng, H. Lane, K.A. Roumeliotis, T.I. Jeggo, P.A. Somaiah, N. Choudhary, J.S. Downs, J.A. (2022). PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance. Genes dev, Vol.36 (13-14), pp. 790-806.  show abstract  full text

Chabanon, R.M. Morel, D. Eychenne, T. Colmet-Daage, L. Bajrami, I. Dorvault, N. Garrido, M. Meisenberg, C. Lamb, A. Ngo, C. Hopkins, S.R. Roumeliotis, T.I. Jouny, S. Hénon, C. Kawai-Kawachi, A. Astier, C. Konde, A. Del Nery, E. Massard, C. Pettitt, S.J. Margueron, R. Choudhary, J.S. Almouzni, G. Soria, J.-. Deutsch, E. Downs, J.A. Lord, C.J. Postel-Vinay, S. (2021). PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer. Cancer res, Vol.81 (11), pp. 2888-2902.  show abstract

Wilkins, A. Fontana, E. Nyamundanda, G. Ragulan, C. Patil, Y. Mansfield, D. Kingston, J. Errington-Mais, F. Bottomley, D. von Loga, K. Bye, H. Carter, P. Tinkler-Hundal, E. Noshirwani, A. Downs, J. Dillon, M. Demaria, S. Sebag-Montefiore, D. Harrington, K. West, N. Melcher, A. Sadanandam, A. (2021). Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer. J immunother cancer, Vol.9 (3).  show abstract  full text

Flaus, A. Downs, J.A. Owen-Hughes, T. (2021). Histone isoforms and the oncohistone code. Curr opin genet dev, Vol.67, pp. 61-66.  show abstract  full text

Lindenburg, L.H. Pantelejevs, T. Gielen, F. Zuazua-Villar, P. Butz, M. Rees, E. Kaminski, C.F. Downs, J.A. Hyvönen, M. Hollfelder, F. (2021). Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. Proc natl acad sci u s a, Vol.118 (46).  show abstract  full text

Anbalagan, S. Ström, C. Downs, J.A. Jeggo, P.A. McBay, D. Wilkins, A. Rothkamm, K. Harrington, K.J. Yarnold, J.R. Somaiah, N. (2021). TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells. Sci rep, Vol.11 (1), p. 7119.  show abstract  full text

Harrod, A. Lane, K.A. Downs, J.A. (2020). The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks. Dna repair (amst), Vol.93, pp. 102919-102919.  show abstract  full text

Rother, M.B. Pellegrino, S. Smith, R. Gatti, M. Meisenberg, C. Wiegant, W.W. Luijsterburg, M.S. Imhof, R. Downs, J.A. Vertegaal, A.C. Huet, S. Altmeyer, M. van Attikum, H. (2020). CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks. Nat commun, Vol.11 (1), p. 5775.  show abstract  full text

Benstead-Hume, G. Chen, X. Hopkins, S.R. Lane, K.A. Downs, J.A. Pearl, F.M. (2019). Predicting synthetic lethal interactions using conserved patterns in protein interaction networks. Plos comput biol, Vol.15 (4), p. e1006888.  show abstract  full text

Benstead-Hume, G. Wooller, S.K. Downs, J.A. Pearl, F.M. (2019). Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers. Int j mol sci, Vol.20 (22).  show abstract  full text

Meisenberg, C. Pinder, S.I. Hopkins, S.R. Wooller, S.K. Benstead-Hume, G. Pearl, F.M. Jeggo, P.A. Downs, J.A. (2019). Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability. Mol cell, Vol.73 (2), pp. 212-223.e7.  show abstract  full text

Jeggo, P.A. Downs, J.A. Gasser, S.M. (2017). Chromatin modifiers and remodellers in DNA repair and signalling. Philos trans r soc lond b biol sci, Vol.372 (1731).  full text

Hopkins, S.R. McGregor, G.A. Murray, J.M. Downs, J.A. Savic, V. (2016). Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180. Dna repair (amst), Vol.46, pp. 47-54.  show abstract

Myrianthopoulos, V. Gaboriaud-Kolar, N. Tallant, C. Hall, M.-. Grigoriou, S. Brownlee, P.M. Fedorov, O. Rogers, C. Heidenreich, D. Wanior, M. Drosos, N. Mexia, N. Savitsky, P. Bagratuni, T. Kastritis, E. Terpos, E. Filippakopoulos, P. Müller, S. Skaltsounis, A.-. Downs, J.A. Knapp, S. Mikros, E. (2016). Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. J med chem, Vol.59 (19), pp. 8787-8803.  show abstract  full text

Meisenberg, C. Ashour, M.E. El-Shafie, L. Liao, C. Hodgson, A. Pilborough, A. Khurram, S.A. Downs, J.A. Ward, S.E. El-Khamisy, S.F. (2016). Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic acids res, .  show abstract  full text

Alatwi, H.E. Downs, J.A. (2015). Removal of H2A Z by INO80 promotes homologous recombination. Embo rep, Vol.16 (8), pp. 986-994.  show abstract  full text

Brownlee, P.M. Meisenberg, C. Downs, J.A. (2015). The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis. Dna repair (amst), Vol.32, pp. 127-133.  show abstract

Niimi, A. Hopkins, S.R. Downs, J.A. Masutani, C. (2015). The BAH domain of BAF180 is required for PCNA ubiquitination. Mutat res, Vol.779, pp. 16-23.  show abstract

Schalbetter, S.A. Mansoubi, S. Chambers, A.L. Downs, J.A. Baxter, J. (2015). Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability. Proc natl acad sci u s a, Vol.112 (33), pp. E4565-E4570.  show abstract

Kakarougkas, A. Downs, J.A. Jeggo, P.A. (2015). The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks. Mol cell oncol, Vol.2 (1), p. e970072.  show abstract

Kakarougkas, A. Ismail, A. Chambers, A.L. Riballo, E. Herbert, A.D. Künzel, J. Löbrich, M. Jeggo, P.A. Downs, J.A. (2014). Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Mol cell, Vol.55 (5), pp. 723-732.  show abstract  full text

Pal, M. Morgan, M. Phelps, S.E. Roe, S.M. Parry-Morris, S. Downs, J.A. Polier, S. Pearl, L.H. Prodromou, C. (2014). Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. Structure, Vol.22 (6), pp. 805-818.  show abstract

Jeggo, P.A. Downs, J.A. (2014). Roles of chromatin remodellers in DNA double strand break repair. Exp cell res, Vol.329 (1), pp. 69-77.  show abstract

López-Perrote, A. Alatwi, H.E. Torreira, E. Ismail, A. Ayora, S. Downs, J.A. Llorca, O. (2014). Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases. J biol chem, Vol.289 (33), pp. 22614-22629.  show abstract

Brownlee, P.M. Chambers, A.L. Cloney, R. Bianchi, A. Downs, J.A. (2014). BAF180 promotes cohesion and prevents genome instability and aneuploidy. Cell rep, Vol.6 (6), pp. 973-981.  show abstract  full text

Chambers, A.L. Pearl, L.H. Oliver, A.W. Downs, J.A. (2013). The BAH domain of Rsc2 is a histone H3 binding domain. Nucleic acids res, Vol.41 (19), pp. 9168-9182.  show abstract

Chambers, A.L. Ormerod, G. Durley, S.C. Sing, T.L. Brown, G.W. Kent, N.A. Downs, J.A. (2012). The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Genes dev, Vol.26 (23), pp. 2590-2603.  show abstract

Brownlee, P.M. Chambers, A.L. Oliver, A.W. Downs, J.A. (2012). Cancer and the bromodomains of BAF180. Biochem soc trans, Vol.40 (2), pp. 364-369.  show abstract

Niimi, A. Chambers, A.L. Downs, J.A. Lehmann, A.R. (2012). A role for chromatin remodellers in replication of damaged DNA. Nucleic acids res, Vol.40 (15), pp. 7393-7403.  show abstract

Chambers, A.L. Downs, J.A. (2012). The RSC and INO80 chromatin-remodeling complexes in DNA double-strand break repair. Prog mol biol transl sci, Vol.110, pp. 229-261.  show abstract

Chambers, A.L. Brownlee, P.M. Durley, S.C. Beacham, T. Kent, N.A. Downs, J.A. (2012). The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses. Plos one, Vol.7 (2), p. e32016.  show abstract

Foster, E.R. Downs, J.A. (2009). Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation. J cell biol, Vol.184 (5), pp. 631-638.  show abstract

Titman, C.M. Downs, J.A. Oliver, S.G. Carmichael, P.L. Scott, A.D. Griffin, J.L. (2009). A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae. Mol biosyst, Vol.5 (12), pp. 1913-1924.  show abstract

Downs, J.A. (2008). Histone H3 K56 acetylation, chromatin assembly, and the DNA damage checkpoint. Dna repair (amst), Vol.7 (12), pp. 2020-2024.  show abstract

Bilsland, E. Hult, M. Bell, S.D. Sunnerhagen, P. Downs, J.A. (2007). The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage. Dna repair (amst), Vol.6 (10), pp. 1471-1484.  show abstract

Downs, J.A. (2007). Chromatin structure and DNA double-strand break responses in cancer progression and therapy. Oncogene, Vol.26 (56), pp. 7765-7772.  show abstract

Chambers, A.L. Downs, J.A. (2007). The contribution of the budding yeast histone H2A C-terminal tail to DNA-damage responses. Biochem soc trans, Vol.35 (Pt 6), pp. 1519-1524.  show abstract

Downs, J.A. Nussenzweig, M.C. Nussenzweig, A. (2007). Chromatin dynamics and the preservation of genetic information. Nature, Vol.447 (7147), pp. 951-958.  show abstract

Kent, N.A. Chambers, A.L. Downs, J.A. (2007). Dual chromatin remodeling roles for RSC during DNA double strand break induction and repair at the yeast MAT locus. J biol chem, Vol.282 (38), pp. 27693-27701.  show abstract

Bilsland, E. Downs, J.A. (2005). Tails of histones in DNA double-strand break repair. Mutagenesis, Vol.20 (3), pp. 153-163.  show abstract

Harvey, A.C. Jackson, S.P. Downs, J.A. (2005). Saccharomyces cerevisiae histone H2A Ser122 facilitates DNA repair. Genetics, Vol.170 (2), pp. 543-553.  show abstract

Foster, E.R. Downs, J.A. (2005). Histone H2A phosphorylation in DNA double-strand break repair. Febs j, Vol.272 (13), pp. 3231-3240.  show abstract

Zaid, O. Downs, J.A. (2005). Histones as tumour suppressor genes. Cell mol life sci, Vol.62 (15), pp. 1653-1656.  show abstract  full text

Downs, J.A. Côté, J. (2005). Dynamics of chromatin during the repair of DNA double-strand breaks. Cell cycle, Vol.4 (10), pp. 1373-1376.  show abstract

Wardleworth, B.N. Downs, J.A. (2005). Spotting new DNA damage-responsive chromatin-binding proteins. Biochem j, Vol.388 (Pt 1), pp. e1-e2.  show abstract  full text

Downs, J.A. Jackson, S.P. (2004). A means to a DNA end: the many roles of Ku. Nat rev mol cell biol, Vol.5 (5), pp. 367-378.

Harvey, A.C. Downs, J.A. (2004). What functions do linker histones provide?. Mol microbiol, Vol.53 (3), pp. 771-775.  show abstract

Downs, J.A. Allard, S. Jobin-Robitaille, O. Javaheri, A. Auger, A. Bouchard, N. Kron, S.J. Jackson, S.P. Côté, J. (2004). Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol cell, Vol.16 (6), pp. 979-990.  show abstract

Downs, J.A. Kosmidou, E. Morgan, A. Jackson, S.P. (2003). Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone. Mol cell, Vol.11 (6), pp. 1685-1692.  show abstract

Buratowski, R.M. Downs, J. Buratowski, S. (2002). Interdependent interactions between TFIIB, TATA binding protein, and DNA. Mol cell biol, Vol.22 (24), pp. 8735-8743.  show abstract  full text

Downs, J.A. Lowndes, N.F. Jackson, S.P. (2000). A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature, Vol.408 (6815), pp. 1001-1004.  show abstract

Downs, J.A. Jackson, S.P. (1999). Involvement of DNA end-binding protein Ku in Ty element retrotransposition. Mol cell biol, Vol.19 (9), pp. 6260-6268.  show abstract

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