Research Projects
Regulated cell cycle progression is dependent upon controlled ubiquitin dependent proteolysis, mediated by the SCF and the anaphase promoting complex or cyclosome (APC/C), coupled to reversible protein phosphorylation.
DOCK proteins have been implicated in the activation of Rac and Cdc42 in cell migration, morphogenesis and phagocytosis, and as important components of tumour cell movement and invasion.
The C-terminal CAAX motif of Ras, and numerous small GTPases undergoes post-translational modification by a sequence of enzymatic reactions that determines the ultimate localisation of Ras to the cell membrane.
The RAS-RAF-MEK-ERK signalling pathway relays extracellular stimuli to changes in cellular function and gene expression. Aberrant activation of this pathway through oncogenic mutations is responsible for a large proportion of human cancer.