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Journal Articles

Patin, E.C. Nenclares, P. Chan Wah Hak, C. Dillon, M.T. Patrikeev, A. McLaughlin, M. Grove, L. Foo, S. Soliman, H. Barata, J.P. Marsden, J. Baldock, H. Gkantalis, J. Roulstone, V. Kyula, J. Burley, A. Hubbard, L. Pedersen, M. Smith, S.A. Clancy-Thompson, E. Melcher, A.A. Ono, M. Rullan, A. Harrington, K.J. (2024). Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy. Nat commun, Vol.15 (1), p. 6923.  show abstract  full text

Dillon, M.T. Guevara, J. Mohammed, K. Patin, E.C. Smith, S.A. Dean, E. Jones, G.N. Willis, S.E. Petrone, M. Silva, C. Thway, K. Bunce, C. Roxanis, I. Nenclares, P. Wilkins, A. McLaughlin, M. Jayme-Laiche, A. Benafif, S. Nintos, G. Kwatra, V. Grove, L. Mansfield, D. Proszek, P. Martin, P. Moore, L. Swales, K.E. Banerji, U. Saunders, M.P. Spicer, J. Forster, M.D. Harrington, K.J. (2024). Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation. J clin invest, Vol.134 (2).  show abstract  full text

Patin, E.C. Dillon, M.T. Nenclares, P. Grove, L. Soliman, H. Leslie, I. Northcote, D. Bozhanova, G. Crespo-Rodriguez, E. Baldock, H. Whittock, H. Baker, G. Kyula, J. Guevara, J. Melcher, A.A. Harper, J. Ghadially, H. Smith, S. Pedersen, M. McLaughlin, M. Harrington, K.J. (2022). Harnessing radiotherapy-induced NK-cell activity by combining DNA damage-response inhibition and immune checkpoint blockade. J immunother cancer, Vol.10 (3).  show abstract  full text

Barber, P.R. Mustapha, R. Flores-Borja, F. Alfano, G. Ng, K. Weitsman, G. Dolcetti, L. Suwaidan, A.A. Wong, F. Vicencio, J.M. Galazi, M. Opzoomer, J.W. Arnold, J.N. Thavaraj, S. Kordasti, S. Doyle, J. Greenberg, J. Dillon, M.T. Harrington, K.J. Forster, M. Coolen, A.C. Ng, T. (2022). Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development. Elife, Vol.11.  show abstract  full text

Melake, M.J. Smith, H.G. Mansfield, D. Davies, E. Dillon, M.T. Wilkins, A.C. Patin, E.C. Pedersen, M. Buus, R. Melcher, A.A. Thway, K. Miah, A.B. Zaidi, S.H. Hayes, A.J. Fenton, T.R. Harrington, K.J. McLaughlin, M. (2022). OX40 and 4-1BB delineate distinct immune profiles in sarcoma. Oncoimmunology, Vol.11 (1), p. 2066050.  show abstract  full text

Wilkins, A. Fontana, E. Nyamundanda, G. Ragulan, C. Patil, Y. Mansfield, D. Kingston, J. Errington-Mais, F. Bottomley, D. von Loga, K. Bye, H. Carter, P. Tinkler-Hundal, E. Noshirwani, A. Downs, J. Dillon, M. Demaria, S. Sebag-Montefiore, D. Harrington, K. West, N. Melcher, A. Sadanandam, A. (2021). Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer. J immunother cancer, Vol.9 (3).  show abstract  full text

McLaughlin, M. Patin, E.C. Pedersen, M. Wilkins, A. Dillon, M.T. Melcher, A.A. Harrington, K.J. (2020). Inflammatory microenvironment remodelling by tumour cells after radiotherapy. Nat rev cancer, Vol.20 (4), pp. 203-217.  show abstract  full text

McLaughlin, M. Pedersen, M. Roulstone, V. Bergerhoff, K.F. Smith, H.G. Whittock, H. Kyula, J.N. Dillon, M.T. Pandha, H.S. Vile, R. Melcher, A.A. Harrington, K.J. (2020). The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism. Mol ther oncolytics, Vol.16, pp. 238-249.  show abstract  full text

Dillon, M.T. Bergerhoff, K.F. Pedersen, M. Whittock, H. Crespo-Rodriguez, E. Patin, E.C. Pearson, A. Smith, H.G. Paget, J.T. Patel, R.R. Foo, S. Bozhanova, G. Ragulan, C. Fontana, E. Desai, K. Wilkins, A.C. Sadanandam, A. Melcher, A. McLaughlin, M. Harrington, K.J. (2019). ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment. Clin cancer res, Vol.25 (11), pp. 3392-3403.  show abstract  full text

Smith, H.G. Mansfield, D. Roulstone, V. Kyula-Currie, J.N. McLaughlin, M. Patel, R.R. Bergerhoff, K.F. Paget, J.T. Dillon, M.T. Khan, A. Melcher, A. Thway, K. Harrington, K.J. Hayes, A.J. (2019). PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma. Clin cancer res, Vol.25 (11), pp. 3443-3454.  show abstract  full text

Forster, M.D. Dillon, M.T. Kocsis, J. Remenár, É. Pajkos, G. Rolland, F. Greenberg, J. Harrington, K.J. (2019). Patritumab or placebo, with cetuximab plus platinum therapy in recurrent or metastatic squamous cell carcinoma of the head and neck: A randomised phase II study. Eur j cancer, Vol.123, pp. 36-47.  show abstract  full text

Dillon, M.T. Grove, L. Newbold, K.L. Shaw, H. Brown, N.F. Mendell, J. Chen, S. Beckman, R.A. Jennings, A. Ricamara, M. Greenberg, J. Forster, M. Harrington, K.J. (2019). Patritumab with Cetuximab plus Platinum-Containing Therapy in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: An Open-Label, Phase Ib Study. Clin cancer res, Vol.25 (2), pp. 487-495.  show abstract

Dillon, M.T. Boylan, Z. Smith, D. Guevara, J. Mohammed, K. Peckitt, C. Saunders, M. Banerji, U. Clack, G. Smith, S.A. Spicer, J.F. Forster, M.D. Harrington, K.J. (2018). PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours. Clin transl radiat oncol, Vol.12, pp. 16-20.  show abstract  full text

Hafsi, H. Dillon, M.T. Barker, H.E. Kyula, J.N. Schick, U. Paget, J.T. Smith, H.G. Pedersen, M. McLaughlin, M. Harrington, K.J. (2018). Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status. Front oncol, Vol.8, p. 245.  show abstract  full text

Dillon, M.T. Barker, H.E. Pedersen, M. Hafsi, H. Bhide, S.A. Newbold, K.L. Nutting, C.M. McLaughlin, M. Harrington, K.J. (2017). Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei. Mol cancer ther, Vol.16 (1), pp. 25-34.  show abstract  full text

Patel, R. Barker, H.E. Kyula, J. McLaughlin, M. Dillon, M.T. Schick, U. Hafsi, H. Thompson, A. Khoo, V. Harrington, K. Zaidi, S. (2017). An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation. Radiother oncol, Vol.122 (3), pp. 470-475.  show abstract  full text

McLaughlin, M. Barker, H.E. Khan, A.A. Pedersen, M. Dillon, M. Mansfield, D.C. Patel, R. Kyula, J.N. Bhide, S.A. Newbold, K.L. Nutting, C.M. Harrington, K.J. (2017). HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation. Bmc cancer, Vol.17 (1), p. 86.  show abstract  full text

Dillon, M.T. Harrington, K.J. (2015). Human Papillomavirus-Negative Pharyngeal Cancer. J clin oncol, Vol.33 (29), pp. 3251-3261.  show abstract

Dillon, M.T. Good, J.S. Harrington, K.J. (2014). Selective targeting of the G2/M cell cycle checkpoint to improve the therapeutic index of radiotherapy. Clin oncol (r coll radiol), Vol.26 (5), pp. 257-265.  show abstract


Book Chapters

Dillon, M.T. Harrington, K.J. (2018). Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates. Cancer Drug Discovery and Development. (pp. 99-127). Springer International Publishing, ISBN: 9783319758343.

Harrington, K.J. Dillon, M.T. (2015). Biologically Targeted Agents in Head and Neck Cancers. Scott-Brown's Otorhinolarnygology and Head and Neck Surgery, Eighth Edition. CRC Press, ISBN: 9781444175899.

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