Quantitative Elasticity Imaging – Elastic Modulus and its Use for Ionising Radiation Dosimetry

RA Crescenti, JC Bamber, NL Bush, S Webb; in collaboration with P Barbone, Boston University and A Oberai, Rensselaer Polytechnic Institute; N Felix, C Cohen-Bacrie, Supersonic Imagine

Source of funding: Institute of Cancer Research, EPSRC, Boston University, CenSSIS

We have shown that iterative methods of solving the quasistatic inverse elasticity problem work well in combination with gels that undergo radiation-induced polymerisation, to measure and visualise 3D dose distributions that are needed for verifying complex radiotherapy treatments. Similar measurements and images were obtained with shear wave elastography using the Supersonic Imagine Aixplorer™, offering opportunities to develop fast and easy-to-use read-out methods for radiation dosimetry (Figure 4).

Fig. 4. Container of MAGIC gel (a) following exposure to a radiation field designed to produce a depth-dependent dose (b), and the depth dependence of Young’s modulus (c) measured from shear wave elastograms, showing a possible boundary artefact at shallow depths.

In this section

High Frequency Transducers and Arrays

Breast Imaging

Neurosurgical Guidance

Hybrid 3D Strain Image Acquisition Technique

Quantitative elasticity imaging – slip elastography

Porosity and Permeability

Lateral Displacement and Strain Measurement

High resolution and microscopic elastography

Organ Motion Tracking

Clinical Freehand Reflection-Mode Photoacoustic Imaging

Illumination Optimisation for Freehand Reflection-Mode Photoacoustic Imaging

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Dynamic Contrast-Enhanced Ultrasound (DCE-US) for Tumour Response

Acoustically Activated Nanoparticle Agents for Molecular Imaging

Multimodality Imaging of Apoptosis