Dr Sebastian Guettler studied Biology, Molecular and Cell Biology and Biochemistry at the Universities of Jena and Heidelberg (Germany) and undertook his MSc research with Dr Giulio Superti-Furga at EMBL. For his PhD project, Sebastian joined Dr Richard Treisman’s laboratory at the London Research Institute of Cancer Research UK (now part of the Francis Crick Institute) where he studied how actin controls MRTF-A, a transcriptional coactivator of Serum Response Factor (SRF).
For his postdoctoral research, he joined the laboratories of Dr Frank Sicheri and Dr Tony Pawson at the Samuel Lunenfeld Research Institute in Toronto. There, Sebastian uncovered the structural basis of the substrate targeting mechanism to the poly(ADP-ribose)polymerase Tankyrase, thereby enabling the successful prediction of novel Tankyrase substrates and explaining why mutations in the adaptor protein 3BP2 cause cherubism, a rare human disease.
In October 2012, Sebastian joined the Divisions of Structural and Cancer Biology at the ICR. His laboratory studies how ADP-ribosylation regulates cell signalling, in particular Wnt/β-catenin signalling and telomere homeostasis, using a combination of biochemistry, structural biology and cell biology approaches.