HOT

HOT - Randomised phase II trial of hyperbaric oxygen therapy for patients with chronic arm lymphoedema after radiotherapy for early breast cancer.

Disease site: Breast cancer

Treatment modality: Other

Status: In active follow-up

Trial details

The primary aim of HOT was to test the efficacy of hyperbaric oxygen (HBO) therapy in reducing arm lymphoedema in patients suffering long-term adverse effects of high dose radiotherapy for early breast cancer. A secondary aim was to test mechanisms of tissue reperfusion and healing in response to HB. 58 patients were recruited to this trial.

Chief Investigator: Professor J. Yarnold, Royal Marsden NHS Foundation Trust

ICR-CTSU Scientific Lead: Professor Judith Bliss

ISRCTN: 00743708

Sponsor: The Institute of Cancer Research

Funding: Cancer Research UK and the Department of Health

Patient friendly information on HOT at CancerHelp UK

Publications and presentations

Gothard L, Haviland J, Bryson P, et al. Randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema after radiotherapy for cancer. Radiother. Oncol. 2010;97(1):101-07