Wellcome Trust collaboration and licensing opportunity.
Principal Scientist: Professor Caroline Springer
Lysyl oxidase (LOX) is an extracellular enzyme responsible for crosslinking of collagen and elastin. LOX expression is regulated by hypoxia inducible factors (HIFs) and LOX is upregulated in hypoxic tumours. Secreted LOX leads to invasion and metastases and hence inhibitors of LOX should prevent tumour progression and metastases.
For more information contact Angela Kukula or download the PDF flyer.